Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody--I. A new reproducible synthetic method.
Identifieur interne : 004C65 ( Main/Exploration ); précédent : 004C64; suivant : 004C66Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody--I. A new reproducible synthetic method.
Auteurs : RBID : pubmed:8401376English descriptors
- KwdEn :
- Animals, Carcinoembryonic Antigen (immunology), Chelating Agents (chemical synthesis), Chelating Agents (metabolism), Chromatography, High Pressure Liquid, Cross-Linking Reagents (chemical synthesis), Cross-Linking Reagents (metabolism), Drug Stability, Edetic Acid (analogs & derivatives), Edetic Acid (chemistry), Edetic Acid (metabolism), Immunoglobulin Fragments (chemistry), Immunoglobulin Fragments (metabolism), Indium Radioisotopes (chemistry), Indium Radioisotopes (diagnostic use), Isotope Labeling (methods), Mice, Reproducibility of Results.
- MESH :
- chemical , analogs & derivatives : Edetic Acid.
- chemical , chemical synthesis : Chelating Agents, Cross-Linking Reagents.
- chemical , chemistry : Edetic Acid, Immunoglobulin Fragments, Indium Radioisotopes.
- chemical , diagnostic use : Indium Radioisotopes.
- chemical , immunology : Carcinoembryonic Antigen.
- chemical , metabolism : Chelating Agents, Cross-Linking Reagents, Edetic Acid, Immunoglobulin Fragments.
- methods : Isotope Labeling.
- Animals, Chromatography, High Pressure Liquid, Drug Stability, Mice, Reproducibility of Results.
Abstract
The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab')2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.
PubMed: 8401376
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A new reproducible synthetic method.</title><author><name sortKey="Gestin, J F" uniqKey="Gestin J">J F Gestin</name><affiliation wicri:level="1"><nlm:affiliation>INSERM Unit 211, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 211, Nantes</wicri:regionArea><placeName><region type="région">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Faivre Chauvet, A" uniqKey="Faivre Chauvet A">A Faivre-Chauvet</name></author><author><name sortKey="Mease, R C" uniqKey="Mease R">R C Mease</name></author><author><name sortKey="Sai Maurel, C" uniqKey="Sai Maurel C">C Sai-Maurel</name></author><author><name sortKey="Thedrez, P" uniqKey="Thedrez P">P Thédrez</name></author><author><name sortKey="Slinkin, M" uniqKey="Slinkin M">M Slinkin</name></author><author><name sortKey="Meinken, G E" uniqKey="Meinken G">G E Meinken</name></author><author><name sortKey="Srivastava, S C" uniqKey="Srivastava S">S C Srivastava</name></author><author><name sortKey="Chatal, J F" uniqKey="Chatal J">J F Chatal</name></author></titleStmt><publicationStmt><date when="1993">1993</date><idno type="RBID">pubmed:8401376</idno><idno type="pmid">8401376</idno><idno type="wicri:Area/Main/Corpus">004F06</idno><idno type="wicri:Area/Main/Curation">004F06</idno><idno type="wicri:Area/Main/Exploration">004C65</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carcinoembryonic Antigen (immunology)</term><term>Chelating Agents (chemical synthesis)</term><term>Chelating Agents (metabolism)</term><term>Chromatography, High Pressure Liquid</term><term>Cross-Linking Reagents (chemical synthesis)</term><term>Cross-Linking Reagents (metabolism)</term><term>Drug Stability</term><term>Edetic Acid (analogs & derivatives)</term><term>Edetic Acid (chemistry)</term><term>Edetic Acid (metabolism)</term><term>Immunoglobulin Fragments (chemistry)</term><term>Immunoglobulin Fragments (metabolism)</term><term>Indium Radioisotopes (chemistry)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Isotope Labeling (methods)</term><term>Mice</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Edetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Chelating Agents</term><term>Cross-Linking Reagents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Edetic Acid</term><term>Immunoglobulin Fragments</term><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Carcinoembryonic Antigen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chelating Agents</term><term>Cross-Linking Reagents</term><term>Edetic Acid</term><term>Immunoglobulin Fragments</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Isotope Labeling</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromatography, High Pressure Liquid</term><term>Drug Stability</term><term>Mice</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab')2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8401376</PMID><DateCreated><Year>1993</Year><Month>11</Month><Day>16</Day></DateCreated><DateCompleted><Year>1993</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0969-8051</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>6</Issue><PubDate><Year>1993</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Nuclear medicine and biology</Title><ISOAbbreviation>Nucl. Med. Biol.</ISOAbbreviation></Journal><ArticleTitle>Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody--I. A new reproducible synthetic method.</ArticleTitle><Pagination><MedlinePgn>755-62</MedlinePgn></Pagination><Abstract><AbstractText>The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab')2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gestin</LastName><ForeName>J F</ForeName><Initials>JF</Initials><Affiliation>INSERM Unit 211, Nantes, France.</Affiliation></Author><Author ValidYN="Y"><LastName>Faivre-Chauvet</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mease</LastName><ForeName>R C</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Sai-Maurel</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Thédrez</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Slinkin</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Meinken</LastName><ForeName>G E</ForeName><Initials>GE</Initials></Author><Author ValidYN="Y"><LastName>Srivastava</LastName><ForeName>S C</ForeName><Initials>SC</Initials></Author><Author ValidYN="Y"><LastName>Chatal</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ENGLAND</Country><MedlineTA>Nucl Med Biol</MedlineTA><NlmUniqueID>9304420</NlmUniqueID><ISSNLinking>0969-8051</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Carcinoembryonic Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Cross-Linking Reagents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Immunoglobulin Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>482-54-2</RegistryNumber><NameOfSubstance>CDTA</NameOfSubstance></Chemical><Chemical><RegistryNumber>9G34HU7RV0</RegistryNumber><NameOfSubstance>Edetic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carcinoembryonic Antigen</DescriptorName><QualifierName MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chelating Agents</DescriptorName><QualifierName MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cross-Linking Reagents</DescriptorName><QualifierName MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Drug Stability</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Edetic Acid</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunoglobulin Fragments</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Isotope Labeling</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate 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